红细胞谷氨和瘤对化疗的反应
A Hercbergs1, F Brok-Simoni, F Holtzman
1Department of Radiation Therapy, Cleveland Clinic Foundation, Ohio 44195-5213.
Lancet (London, England)
|May 2, 1992
概括
瘤谷氨 (GSH) 度会影响化疗耐药性. 测量血液中的红细胞GSH可以预测患者对癌症治疗的反应,避免侵入性瘤采样.
科学领域:
- 在瘤学瘤学.
- 生物化学 生物化学
- 临床医学 临床医学
背景情况:
- 瘤谷氨 (GSH) 水平与化疗耐药性有关.
- 直接测量瘤GSH是侵入性的,对于例行患者护理是不切实际的.
研究的目的:
- 调查红细胞GSH度与癌症患者化疗反应之间的相关性.
- 确定外周血液GSH水平是否可以作为瘤GSH的替代标记物,并预测治疗结果.
主要方法:
- 谱光测量用于测量周围血液样本中的红细胞GSH度.
- 患者包括那些患有晚期乳腺癌和接受常规化疗的其他瘤类型的患者.
- 在治疗前和治疗后进行测量,以评估变化和相关性.
主要成果:
- 在获得化学疗法的完全或部分反应的患者中观察到较低的治疗前红细胞GSH度.
- 这一发现在晚期乳腺癌队列和其他瘤队列中是一致的.
- 在响应者和非响应者之间发现了平均GSH水平的统计学上显著差异 (p < 0.01).
结论:
- 红细胞GSH度与化疗反应率相关.
- 测量红细胞GSH可能提供一种非侵入性方法来预测患者对癌症治疗的反应.
- 这种方法可以帮助为癌症患者制定个性化治疗策略.
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