波罗的海和地中海的基因位点是相同的
A Malafosse1, A E Lehesjoki, P Genton
1INSERM U249, CNRS UPR8402, Montpellier, France.
Lancet (London, England)
|May 2, 1992
概括
遗传链接分析显示,波罗的海和地中海肌类型的渐进性肌性与染色体21标记物D21S113.3有关. 这些情况可能源于同一基因的突变.
科学领域:
- 遗传学 是一个遗传学.
- 神经学 神经学
- 分子生物学分子生物学
背景情况:
- 渐进性肌性 (PME) 包含了几种罕见的遗传神经系统疾病.
- 波罗的海肌和地中海肌是PME的不同的临床表型.
研究的目的:
- 为了研究波罗的海和地中海的遗传基础myoclonus.
- 为了确定负责这些PME形式的基因的染色体位置.
主要方法:
- 进行了遗传联系分析.
- 在21号染色体上使用了标记物D21S113.
主要成果:
- 在波罗的海和地中海菌株和标记物D21S113.3之间建立了显著的遗传联系.
- 负责这两种疾病的基因位于21号染色体的长臂.
结论:
- 波罗的海和地中海的肌细胞菌是基因相关的,可能是由同一基因的突变引起的.
- 涉及这些PME形式的基因位于21号染色体上.
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