胰岛素耐药性和吸烟方式
F S Facchini1, C B Hollenbeck, J Jeppesen
1Department of Medicine, Stanford University School of Medicine, California.
吸烟会导致胰岛素抵抗和不健康的脂质样本,增加冠状动脉心脏病的风险. 吸烟者表现出较高的甘油三和较低的HDL胆固醇,以及受损的葡萄糖吸收.
科学领域:
- 内分泌学 在内分泌学.
- 心血管疾病研究研究
- 代谢综合征是代谢综合征的一种.
背景情况:
- 吸烟与不良的脂质特征有关,包括高甘油和降低高密度脂蛋白胆固醇.
- 这些脂质变化与冠状动脉心脏病 (CHD) 风险增加有关,可能与胰岛素抵抗和高胰岛素血症有关.
研究的目的:
- 为了研究慢性吸烟和胰岛素介导的葡萄糖摄取之间的关系.
- 为了比较吸烟者和非吸烟者之间的脂质特征,葡萄糖-胰岛素反应和胰岛素敏感性.
主要方法:
- 这是一项涉及40名健康志愿者的横截面研究 (20名吸烟者,20名非吸烟者).
- 测量包括血脂和脂蛋白度,血葡萄糖和胰岛素对口服葡萄糖挑战的反应,以及通过高胰岛素血糖-欧糖 (通过葡萄糖-胰岛素-体质素注入模拟) 通过胰岛素介导的葡萄糖吸收.
主要成果:
- 与非吸烟者相比,吸烟者表现出明显更高的非常低密度脂蛋白 (VLDL) 三甘油和胆固醇,以及较低的高密度脂蛋白胆固醇 (HDL-C).
- 尽管口服葡萄糖挑战后血葡萄糖水平相似,但吸烟者表现出显著更高的血胰岛素反应.
- 吸烟者表现出胰岛素中介葡萄糖吸收受损,在葡萄糖-胰岛素-体静止素输注期间稳定状态血葡萄糖度较高,尽管稳定状态胰岛素水平相比较.
结论:
- 慢性吸烟会在健康人群中诱导胰岛素抵抗,高胰岛素血症和脂质失调症.
- 吸烟者的这些代谢和脂质异常可能会导致吸烟相关的冠状动脉心脏病风险增加.
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