重新感染Ascaris lumbricoides的强度及其对寄生虫控制的影响
A Hall1, K S Anwar, A M Tomkins
1International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
Lancet (London, England)
|May 23, 1992
概括
个体对肠道线虫感染的易感性各不相同,如阿斯卡里斯 (Ascaris lumbricoides). 大规模除虫更有效地控制了发病率,而不是只针对严重感染的人.
科学领域:
- 医学寄生虫学 医学寄生虫学
- 传染病流行病学 传染病流行病学
- 公共卫生 公共卫生
背景情况:
- 肠道虫引起广泛的人类感染,在某些宿主中聚集表明易感性.
- 控制发病率可能需要针对严重感染的个体,但对再感染模式的证据至关重要.
研究的目的:
- 调查孟加拉国达卡的Ascaris lumbricoides再感染的发生率和强度.
- 评估个人对重型虫感染的易感性,并评估治疗策略.
主要方法:
- 880名参与者接受了六个月间隔三次的pyrantel pamoate治疗.
- 在治疗后的48小时内收集便样本;排出的虫被计数和称重.
主要成果:
- 最初感染的患病率为89% (平均负担为18.5个虫),再感染迅速 (80-82%的患病率,11.5-14.0个虫).
- 虫强度是非随机聚合的;个体总是轻度或重度感染 (p<0.001).
- 虽然每一轮有10%的人被严重感染,但超过60%的人至少被一次严重感染.
结论:
- 个体对严重的Ascaris lumbricoides感染存在敏感性.
- 大规模化疗似乎比对严重感染个体的选择性治疗更有效控制发病率.
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