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Published on: March 19, 2017
在儿童中出现表面活性剂异常,并出现反复复发的蓝色情节
B A Hills1, I B Masters, J F O'Duffy
1Mater Children's Hospital, South Brisbane, Queensland, Australia.
Lancet (London, England)
|May 30, 1992
概括
儿童中反复出现的蓝色发作可能源于表面活性剂缺乏. 在受影响的儿童中观察到较低的表面活性剂量和异常的物理特性,这表明潜在的诊断标志物.
科学领域:
- 儿科肺病学 儿科肺病学
- 生物化学 生物化学
- 呼吸系统生理学 呼吸系统生理学
背景情况:
- 在婴儿和儿童中,反复出现的蓝色发作是一个鲜为人知的临床问题.
- 表面活性剂缺乏被假设为这些事件的潜在潜在原因.
研究的目的:
- 调查肺表面活性剂在反复出现的蓝色病发作中的作用.
- 为了比较受影响儿童和对照组之间的表面活性剂数量和物理性质.
- 探索表面活性剂分析作为诊断工具的潜力.
主要方法:
- 支气管支气管洗用于从儿童中收集表面活性剂,这些儿童有反复出现的蓝色情节和对照.
- 表面活性剂的物理性质是通过在不同表面积 (A) 上测量表面张力 () 来评估的.
- 分析包括对表面活性剂量的定量测量和对玛/A环的定性评估.
主要成果:
- 与对照组相比,患有反复出现的蓝色色情节的儿童表现出较少量的提取的表面活性剂.
- 在这些病例中观察到玛/A环异常.
- 在这些案例中发现了定性异常,特别是反向的循环 (压缩时的表面张力高于膨胀时的表面张力).
结论:
- 减少表面活性剂的数量和表面活性剂物理性质的定性异常可能与反复出现的蓝色情节有关.
- 观察到的表面活性物异常表明了这种情况的潜在诊断测试.
- 需要进一步的研究来阐明将表面活性剂功能障碍与蓝色情节联系在一起的确切机制.
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