在皮肤透光冠状动脉血管塑造过程中侧枝封闭
1Department of Medical Chemistry, University of Innsbruck Medical School, Austria.
Lancet (London, England)
|June 6, 1992
概括
皮肤透光冠状动脉血管塑造术 (PTCA) 可以导致心肌损伤. 在血中测量心脏托罗邦素T有效地分级这种损伤,特别是在PTCA期间侧枝封闭后.
科学领域:
- 心脏病学 心脏病学
- 生物标志物 生物标志物
- 干预心脏病学 干预心脏病学
背景情况:
- 皮肤透光冠状动脉血管形成术 (PTCA) 是一种常见的手术.
- 心肌损伤可以在PTCA期间发生,有时没有明显的临床症状.
- 评估心肌损伤的程度对于患者管理至关重要.
研究的目的:
- 评价肌酸激酶 (CK) MB质量和心脏素T测量的实用性,用于在PTCA后检测和分级心肌损伤.
- 为了确定心脏托罗邦素T是否比CK MB质量更为敏感的标志物,用于PTCA期间心肌损伤.
主要方法:
- 从21名接受PTCA的患者收集了连续的外周静脉血液样本.
- 测量了CK MB质量和心脏托罗邦尼T的度.
- 血管造影被用来评估侧枝闭塞.
- 对心肌损伤的临床迹象进行了监测.
主要成果:
- 在PTCA期间,五名患者经历了侧枝封闭.
- 所有5名侧枝闭塞的患者都显示CK MB质量度升高.
- 在这5名患者中,有3名患者心脏中托罗邦尼T度升高.
- 没有侧枝阻塞的患者仅在CKMB质量和托罗邦尼T中略有增加.
- 心脏中托罗邦素T水平与肌肉心脏损伤的严重程度相关.
结论:
- 心脏热素T是一种敏感的生物标志物,用于检测PTCA后的心肌损伤,特别是在侧枝封闭的情况下.
- 测量心脏托波宁T可以有效地分级侧枝闭塞引起的心肌损伤的严重程度.
- 心脏中托罗邦素T释放表明肌细胞损伤比CK MB大规模泄漏更为显著.
相关概念视频
Regulation of Angiogenesis and Blood Supply
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...
Development of Blood Vessels
The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...


