尼费迪平因尼费迪平诱导的牙过度生长而导致的尼费迪平的牙封存
J S Ellis1, R A Seymour, S C Monkman
1Department of Operative Dentistry, Dental School, University of Newcastle upon Tyne, UK.
Lancet (London, England)
|June 6, 1992
概括
长期使用尼菲迪平可以导致牙过度生长. 尼菲迪平在牙裂液中的高度,但不是血,表明组织封存有助于这种副作用.
科学领域:
- 药理学 药理学是指药理学的学科.
- 口腔医学是指口腔医学.
- 生物化学 生物化学
背景情况:
- 牙过度生长是影响平衡的某些药物的已知副作用,包括尼菲迪平,环素和丁素.
- 药物诱导的牙过度生长背后的确切机制尚不清楚.
研究的目的:
- 调查nifedipine在血和牙裂液 (GCF) 中的药理动力学概况.
- 探索GCF中尼菲迪平度与牙过度生长的发生之间的潜在关系.
主要方法:
- 使用超敏度测试来测量尼费迪平度.
- 尼费迪平的药理动力学分析了9名接受长期尼费迪平治疗心痛和高血压的患者的血和GCF.
主要成果:
- 在9名患者中,有7名患者在GCF中表现出与血相比显著更高的尼菲迪平最大度 (比血大15-316倍).
- 这两名患有无法检测到GCF尼菲迪平水平的患者没有出现牙过度生长.
结论:
- 牙组织似乎可以隔离尼菲迪平,导致本地药物度大幅增加.
- 这些高度的尼菲迪平在牙组织中被认为是导致牙过度生长的关键因素.
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