用表达狂犬病葡萄糖蛋白的天花病毒进行免疫
M Cadoz1, A Strady, B Meignier
1Centre Hospitalier Régional, Universitaire de Reims, France.
Lancet (London, England)
|June 13, 1992
概括
雀病毒是一种比疫苗更安全的替代品,作为疫苗载体显示出希望. 复合性狂犬病表达性狂犬病糖蛋白 (ALVAC-RG) 诱导了人类的保护性狂犬病抗体,具有轻微的副作用.
科学领域:
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 麻疹病毒是有效的基因载体,但疫苗病毒的安全性是令人担忧的.
- 像金雀这样的鸟类天花病毒提供了一个更安全的替代方案,因为它在哺乳动物细胞中失败的复制.
- 雀病毒使病毒抗原向免疫系统呈现.
研究的目的:
- 评估一种表达狂犬病糖蛋白G基因的复合性天花病毒载体 (ALVAC-RG) 的安全性和有效性.
- 在1期临床试验中评估ALVAC-RG的免疫性和安全性,该试验涉及人类志愿者.
主要方法:
- 构建了编码狂犬病糖蛋白G基因的复合性野病毒 (ALVAC-RG).
- 安全性和有效性在动物身上进行了测试,随后进行了1期临床试验,包括25名志愿者.
- 志愿者接受了不同剂量的ALVAC-RG或人类双胞胎细胞培养疫苗 (HDC) 的皮下注射.
主要成果:
- 在志愿者中,ALVAC-RG诱导狂犬病中和抗体,更高剂量显示出更高的疗效.
- 在最高的ALVAC-RG剂量组中,抗体水平接近了在动物中观察到的保护水平.
- 6个月后的强剂量在所有接种疫苗的群体中引起了召回免疫反应.
- 报告的副作用是轻微的,短暂的,与HDC疫苗相当.
结论:
- 非复制性天花病毒,如天花,是人类疫苗接种的潜在载体.
- 阿尔瓦克-RG显示出可接受的安全性,并诱导了对狂犬病的免疫反应.
- 对于大麻病毒复合物,需要进行更多的高剂量和替代性注射途径的进一步试验.
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