轻度宫硬化症:细胞学监测的安全性
Lancet (London, England)
|June 13, 1992
概括
在宫部查上管理轻度硬化症是有争议的. 单靠细胞监测就有缺失宫内皮质新生病 (CIN) 3病变的风险,但添加第三次涂抹可以显著降低这种风险.
科学领域:
- 妇科 妇科 妇科 妇科
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 在宫部查中治疗轻度硬化症仍然存在争议.
- 结肠镜检查是有效的,但对许多女性来说,结果正常,但在情感上是很累的.
- 细胞学监测可能会忽略显著的宫病变.
研究的目的:
- 评估宫内皮质瘤 (CIN) 和人类乳头瘤病毒感染 (HPVI) 在细胞监测中遗漏的比例.
- 为了确定镜检查后是否存在异常.
- 评估对轻度硬化症的管理策略.
主要方法:
- 结肠镜检查和活检用于研究两组先前患有轻度硬化症的患者.
- 第1组:针对持续异常,进行细胞学监测,采用胆管镜检查.
- 第二组:早期的肠镜检查和治疗.
主要成果:
- 在细胞监测组中,平均27个月后,12%的人有CIN3.
- 添加第三次涂抹将CIN3风险降低到4%.
- 在早期的结肠镜组中,37%的人有持续的异常,但没有人有CIN3.
结论:
- 对轻度硬化症的细胞学监测有缺失CIN3病变的风险.
- 涉及第三次重复涂抹的策略可以显著降低这种风险.
- 这种方法平衡了严重癌前变化的检测和减少对结肠镜检查的需求.
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