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在慢性肝病中自主神经病变的自然史
M T Hendrickse1, P J Thuluvath, D R Triger
1Department of Medicine and Pharmacology, Royal Hallamshire Hospital, Sheffield, UK.
Lancet (London, England)
|June 13, 1992
概括
自主神经病变,特别是阴道神经病变,在慢性肝病中很常见. 患有这种疾病的患者面临着明显更高的死亡风险,这突出了其在预后方面的重要性.
科学领域:
- 心脏病学 心脏病学
- 肝病学 肝病学是一种肝病学.
- 神经学 神经学
背景情况:
- 慢性肝病 (CLD) 影响多个器官系统.
- 自主功能障碍是CLD的一个已知的并发症.
- 在CLD中自主神经病变的自然史和预后意义需要进一步阐明.
研究的目的:
- 为了前性地评估CLD患者自主神经病变的患病率和自然史.
- 评估CLD患者自主神经病变和死亡率之间的关联.
- 为了确定这一群体中死亡率的预测因素.
主要方法:
- 对60名具有保存肝功能的CLD患者的前性评估.
- 使用了标准的心血管自主功能测试.
- 进行了连续测试,以监测疾病的进展和可逆性.
主要成果:
- 在最初的测试中,在45%的患者中存在阴道神经病变.
- 自主功能障碍在与酒精有关的和与非酒精有关的肝病中同样普遍.
- 在患有阴道神经病变的患者中,四年死亡率为30%,而在没有阴道神经病变的患者中为6%.
- 阴道神经病变和肝损伤严重程度独立预测死亡率.
结论:
- 阴道功能障碍是补偿良好的慢性肝病的常见发现.
- 阴道神经病变的存在确定了一个具有更糟糕预后的高风险亚组.
- 在CLD中,自主功能异常可能是渐进的或可逆的.
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