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甲状腺和其他器官特异性自身抗体在健康的百岁老人
S Mariotti1, P Sansoni, G Barbesino
1Institute of Endocrinology, University of Pisa, Italy.
甲状腺自身抗体随着年龄的增长而增加,但这种趋势在百岁老人中逆转. 这项研究发现,与年轻的老年人群不同,非常老年人群的患病率并不高.
科学领域:
- 免疫学 免疫学 免疫学
- 老年学是一门学科.
- 内分泌学 在内分泌学.
背景情况:
- 甲状腺自身抗体在一般老年人群中呈现出与年龄相关的患病率增加.
- 以前的研究表明,随着年龄的增长,甲状腺自身免疫性会增加.
研究的目的:
- 在健康的百岁老人中调查甲状腺自身抗体的患病率.
- 为了检查衰老,B细胞种群和甲状腺自身免疫之间的关系.
主要方法:
- 从34名健康的百岁老人 (100-108岁) 的血清中检测甲状腺自身抗体.
- 用细胞化仪分析了周围血液的淋巴细胞.
- 患病率数据与年龄在7-85岁的对照组进行了比较.
主要成果:
- 在百岁以上的人群中,甲状腺自身抗体的患病率与50岁以下人群的患病率相似.
- 甲状腺自身抗体的年龄相关显著增加观察到85岁.
- 百岁老人表现出总和CD5+B细胞的显著年龄相关下降.
结论:
- 甲状腺自身抗体的年龄相关增加不会超过生命的第九个十年.
- 非常老的年龄与B细胞种群的减少有关.
- 百岁以上的人缺少甲状腺自身抗体增加可能与改变的B细胞动态有关.
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