流行性和零星非A,非B型肝炎的常见病因因因子
A Chauhan1, J B Dilawari, S Jameel
1Department of Hepatology, Post-Graduate Institute of Medical Education and Research, Chandigarh, India.
Lancet (London, England)
|June 20, 1992
概括
作为流行病和零星非A,非B (NANB) 型肝炎的原因,研究了类似肠道病毒的颗粒. 这些类似病毒的颗粒 (VLP) 在患者和子中被检测到,这表明它们是两种肝炎类型的致病因.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 病毒学 病毒学
- 胃肠病学 胃肠病学
背景情况:
- 在非A,非B (NANB) 型肝炎病例中观察到类似肠道病毒的颗粒 (VLPs).
- 这些VLP在流行性和零星NANB肝炎中的病因作用仍然不清楚.
研究的目的:
- 调查肠道病毒样颗粒是否是流行性和零星NANB肝炎的致病原体.
- 为了比较流行性和零星性NANB肝炎中发现的VLP的特征.
主要方法:
- 在北印度研究了29名流行病患者和9名偶发性急性病毒性肝炎患者.
- 通过排除诊断的肠道传播的NANB肝炎.
- 在便和血清样本中使用血清交叉反应和IgM反应检测和表征病毒样颗粒 (VLP).
- 接种了感染便的 rhesus 子,以观察临床和病毒学变化.
主要成果:
- 86%的流行性肝炎病例和56%的零星性肝炎病例被诊断为肠道传播的NANB肝炎.
- 在每组的1名患者中检测到VLPs (30-34nm).
- 在急性血清样本中,VLPs显示出血清交叉反应与特定的IgM反应.
- 接种疫苗的子表现出轻微的肝酶升高和胆汁中的VLP.
结论:
- 流行性和零散性NANB肝炎的病因因可能是相同的.
- 强烈建议与肠道病毒类似的颗粒是肠道传播的NANB肝炎的致病原体.
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