长期的甲状腺素治疗和骨矿物质密度
J A Franklyn1, J Betteridge, J Daykin
1Department of Medicine, University of Birmingham, UK.
Lancet (London, England)
|July 4, 1992
概括
长期的甲状腺素替代疗法对差异化甲状腺癌患者的骨矿物密度没有影响. 这项研究表明,单独使用甲状腺素并不会增加骨质疏松性骨折的风险.
科学领域:
- 内分泌学 在内分泌学.
- 骨的新陈代谢 骨的新陈代谢
- 甲状腺疾病 甲状腺疾病
背景情况:
- 关于甲状腺素替代疗法对骨矿物质密度的影响,存在相互矛盾的结果.
- 一些研究表明骨质减少,促使建议减少剂量.
研究的目的:
- 研究甲状腺素治疗对骨矿物质密度的长期影响.
- 为了确定甲状腺素治疗是否影响骨质疏松性骨折的风险.
主要方法:
- 一组49名因差异化甲状腺癌而进行甲状腺切除术后的患者接受了长期的甲状腺素治疗.
- 患者与基于年龄,性别,BMI和生活方式因素的对照进行了匹配.
- 在多个骨部位使用双能X射线吸收计测量骨矿物质密度.
主要成果:
- 长期接受甲状腺素治疗的患者和对照组之间没有观察到骨矿物质密度的显著差异.
- 骨矿物质密度与甲状腺素剂量,治疗时间或甲状腺功能测试无关.
- 两组人都出现了与年龄相关的骨密度下降.
结论:
- 在差异化甲状腺癌治疗的背景下,甲状腺素替代疗法似乎不会对骨矿物质密度产生负面影响.
- 单独的甲状腺素不太可能是骨质疏松性骨折的重要危险因素.
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