在艾滋病患者中传播"Mycobacterium genavense"感染
E C Böttger1, A Teske, P Kirschner
1Institut für Medizinische Mikrobiologie, Medizinische Hochschule Hannover, Germany.
Lancet (London, England)
|July 11, 1992
概括
一种新的Mycobacterium物种,Mycobacterium genavense,在18名艾滋病毒发病患者中引起了传播感染. 这种细菌应考虑在免疫功能低下的个体中,有不明原因的发烧和体重减轻.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
背景情况:
- 晚期艾滋病毒感染往往会出现机会性感染.
- 浪费综合征和慢性发烧在严重免疫功能低下的个体中很常见.
研究的目的:
- 在一组先进的艾滋病毒患者中识别传播感染的致病原体.
- 在受影响个体的多种组织中发现的一种新型微生物的特征.
- 在Mycobacterium属内提出一种新物种.
主要方法:
- 分析了来自18名艾滋病毒发病患者的活检和尸体解剖样本.
- 用显微镜检查酸敏微生物.
- 在固体和液体介质上进行细菌培养试验.
- 来自各种组织和血液培养的细菌16S rRNA的DNA放大和测序.
主要成果:
- 在多个器官中检测到大量的酸性快速微生物.
- 微生物在液体培养物中表现出有限的生长,但在固体介质上没有.
- 获得了独特的DNA序列,表明一种新的细菌物种.
- 这种微生物被确定为Mycobacterium属的新成员,名为Mycobacterium genavense.
结论:
- 麦古巴菌 (Mycobacterium genavense) 是一种新发现的致病原体,负责传播感染.
- 这种感染应在严重免疫功能低下的艾滋病毒感染患者的差异诊断中考虑,这些患者有衰竭和发烧.
- 需要进一步的研究,以了解M. genavense感染的发病和治疗.
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