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Updated: Jun 24, 2026

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
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Published on: September 20, 2018

在cAMP诱导后的转录衰减需要PP-1-介导的CREB脱化

M Hagiwara1, A Alberts, P Brindle

  • 1Clayton Foundation Laboratories for Peptide Biology, Salk Institute, La Jolla, California 92037.

Cell
|July 10, 1992
PubMed
概括

在初始的cAMP诱导后,对cAMP响应的元素结合蛋白 (CREB) 被脱,从而降低了体静止素基因转录. 蛋白酸酶1 (PP-1) 解化CREB,作为其活动的关键调节者.

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