在医生健康研究中,低剂量阿司匹林和随后的外周动脉手术
S Z Goldhaber1, J E Manson, M J Stampfer
1Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
Lancet (London, England)
|July 18, 1992
概括
低剂量阿司匹林显著降低了健康男性的外周动脉手术的需要. 这一发现表明阿司匹林.
科学领域:
- 心血管医学 心血管医学
- 预防性心脏病学 预防性心脏病学
- 临床试验 临床试验
背景情况:
- 周围动脉疾病 (PAD) 是一种严重的血管疾病.
- 周围动脉手术是晚期PAD的常见干预措施.
- 低剂量阿司匹林在预防PAD并发症中的作用需要进一步研究.
研究的目的:
- 研究低剂量阿司匹林对外周动脉手术发生率的影响.
- 测试阿司匹林使用可能减少血管手术的需要的假设.
主要方法:
- 采用了一种随机,双盲,安慰剂控制的试验设计.
- 这项研究涉及22 071名40-84岁的美国男性健康医生.
- 参与者接受了低剂量阿司匹林 (325毫克每隔一天) 或安慰剂.
主要成果:
- 共有56名参与者接受了外围动脉手术 (阿司匹林组20名,安慰剂组36名).
- 周围动脉手术的相对风险在阿司匹林组显着较低 (0.54;95% CI:0.30-0.95;p = 0.03).
结论:
- 在看似健康的男性中,慢性服用低剂量阿司匹林与减少对外周动脉手术的需求有关.
- 这些发现支持阿司匹林在减少外围动脉疾病的主要血管干预中的潜在预防作用.
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