核糖对运动诱导性缺血的作用 在稳定的冠状动脉疾病中
W Pliml1, T von Arnim, A Stäblein
1Department of Medicine, Medizinische Klinik I, Klinikum Grosshadern, Germany.
Lancet (London, England)
|August 29, 1992
概括
里波斯补充剂改善了冠状动脉疾病 (CAD) 患者的心脏缺血耐受性. 这种糖增强了心肌能量代谢,为心脏病提供了潜在的辅助治疗.
科学领域:
- 心脏病学 心脏病学
- 生物化学 生物化学
- 代谢医学是一种代谢医学.
背景情况:
- 心脏能量代谢因缺血而受损,低ATP水平在再输液后持续存在.
- 低ATP含量与长期的缺血后功能障碍和不可逆转的损伤有关.
- 没有确定的治疗方法可以在缺血期间保护或恢复心脏能量代谢.
研究的目的:
- 调查是否补充核糖增加心肌缺血耐受性冠状动脉疾病 (CAD) 患者.
- 评估核糖对心脏ATP合成和在缺血条件下的能量代谢的影响.
主要方法:
- 一个随机的,安慰剂对照试验,涉及20名患有严重CAD的男性.
- 患者每天接受安慰剂或60克核糖,持续3天.
- 在治疗前和治疗后进行了限制症状的跑步机运动测试,以评估缺血耐受性.
主要成果:
- 与安慰剂相比,ribose治疗显著增加了跑步机行走时间,达到1毫米的ST段缩 (276s vs 223s,p=0.002).
- 从基线到第五天,在核糖组中观察到ST抑郁和心痛的时间有显著改善,但在安慰剂组中没有.
- 两组之间没有发现时间到中度心痛的显著差异.
结论:
- 在患有CAD的患者中,口服三天的 riboze 增加了心肌缺血耐受性.
- 据推测对心脏能量代谢的影响表明,核糖糖可以作为心肌缺血的潜在辅助疗法.
- 里波斯可能为管理涉及心脏能量代谢受损的疾病提供新的治疗途径.
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