在巴布亚新几内亚的石灰和贝特尔坚果癌症
1Queensland Institute of Medical Research, Brisbane, Australia.
Lancet (London, England)
|September 5, 1992
概括
巴布亚新几内亚的口腔癌与口角的石灰应用有关. 这种做法提高了口腔的pH值,产生了活性氧物种并促进了细胞增殖,这表明了致癌机制.
科学领域:
- 在瘤学瘤学.
- 口腔病理学 口腔病理学
- 环境健康 环境健康
背景情况:
- 口腔状细胞癌 (OSCC) 是巴布亚新几内亚最常见的恶性瘤.
- 这个地区的OSCC在口角和脸处呈现独特的特征.
- 这与西方人口中典型的口腔癌呈现形成鲜明对比.
研究的目的:
- 调查巴布亚新几内亚口腔癌部位与石灰应用之间的关联.
- 探索石灰和白菜成分对口腔致癌的潜在机制.
主要方法:
- 在巴布亚新几内亚,对169名口腔癌患者进行了回顾性病例分析.
- 在应用石灰的地方测量pH值.
- 在体外分析从贝特尔的成分生成反应性氧物种.
主要成果:
- 在77%的病例中,口腔癌与石灰应用部位有准确的相关性.
- 在的白菜 (Areca坚果和Piper betle花朵) 上应用石灰,使口腔平均pH值提高到10.
- 实验室内研究表明,在pH值升高的情况下,从贝特尔的成分中产生反应性氧物种.
结论:
- 这些发现表明,白种的特殊应用场所和巴布亚新几内亚的口腔状细胞癌之间存在强烈的联系.
- 升高的pH值和随后的反应性氧物种生成,加上石灰诱导的细胞增殖,在这个人群中呈现出口腔致癌的合理机制.
- 这项研究强调了口腔癌的文化特异性风险因素,需要有针对性的公共卫生干预措施.
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