在胎儿生命期间暴露于二甲的效应
1Department of Clinical Pharmacology, Karolinska Institute, Huddinge Hospital, Sweden.
Lancet (London, England)
|September 19, 1992
概括
在怀孕期间服用高剂量的二类药物可能与出生缺陷有关. 然而,这种关联被母亲频繁的酒精和药物滥用所混,这表明它可能不仅仅是由于二胺的暴露.
科学领域:
- 产科和妇科 产科和妇科
- 儿科 儿科 儿科
- 药理学 药理学是指药理学的学科.
背景情况:
- 以前的报道表明,在怀孕期间使用高剂量的二胺与胎儿不良结果 (如形障碍和精神障碍) 之间存在联系.
- 二二类药物的致死性潜力需要进一步调查,特别是考虑到混因素.
研究的目的:
- 调查在怀孕期间使用二胺和胎儿后果之间的关联.
- 评估暴露于高剂量的二类药物后代的先天性异常和其他不良结果的发生率.
主要方法:
- 一项大规模的队列研究,从1980年至1983年,对104,000个在医疗补助 (美国公共医疗保险) 登记的怀孕进行了研究.
- 通过健康声明数据对产后6-9年后代的胎儿结果进行了评估.
- 专注于80个怀孕的10个或更多的二二类药物处方,分析同时发生的药物滥用和医疗保健利用.
主要成果:
- 在80个重量使用二胺的怀孕中,发现了3例子宫内死亡和2例患有先天性异常 (暗示新生儿死亡) 的婴儿.
- 在64名被关联的幸存儿童中,有6名的诊断与原性异常一致.
- 孕产妇的记录表明,大量使用医疗保健,频繁饮酒和滥用药物,这使得隔离二类药物的效应变得更加复杂.
结论:
- 在孕妇大量使用二zepine的怀孕中观察到高水平的产性.
- 观察到的致性发生在多次酒精和物质暴露的同时,这表明这些因素可能会混或导致异常,而不是单独使用二.
- 需要进一步的研究来分离二类药物的影响与怀孕期间其他物质的使用.
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