在运动时从上腺的神经末端释放 (S) - 氨醇的立体选择性释放
K Stoschitzky1, W Lindner, W Klein
1Department of Medicine/Division of Cardiology, Karl-Franzens University, Graz, Austria.
Lancet (London, England)
|September 19, 1992
概括
运动会改变患者的阿提诺洛尔反体水平. 活性形式 (S) - 亚特诺洛尔在运动后增加,这可能会影响服用这种药物的患者的β阻塞管理.
科学领域:
- 药理学 药理学是指药理学的学科.
- 临床药房 临床药房
背景情况:
- 实验室内研究表明,阿丁诺洛尔通过上腺神经末端的立体选择性吸收和释放.
- 膜脱极化影响了阿提诺洛的立体选择性处理.
研究的目的:
- 为了研究在患者中对立体选择性阿提诺洛尔处理的体内相关性.
- 为了评估运动后阿提诺洛尔反体的血度的变化.
主要方法:
- 血液样本从10名长期接受血清性阿提诺洛尔治疗的患者中收集.
- 样品在休息和运动后进行分析,以确定 (R) 和 (S) 乙醇醇的血度.
主要成果:
- 在休息状态下, (R) - 乙烯醇的血度明显高于 (S) - 乙烯醇.
- 在运动后, (S) - 亚特诺洛尔的立体选择性增加,改变了比率.
- (R) 乙醇与 (S) 乙醇的比率从休息时的1.14转变为运动后的0.66 (p < 0.01).
结论:
- 运动会诱导患者在血中阿提诺洛尔反体度的立体选择性变化.
- (S) - 亚特诺洛尔负责临床相关的β-阻断.
- 这些发现表明,对治疗像阿诺洛尔这样的β-阻断剂药物患者的管理有潜在的影响.
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