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相关概念视频

Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
Cells of the Innate Immune Response01:28

Cells of the Innate Immune Response

The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...

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相关实验视频

Updated: Jul 10, 2026

Determining Optimal Cytotoxic Activity of Human Her2neu Specific CD8 T cells by Comparing the Cr51 Release Assay to the xCELLigence System
11:31

Determining Optimal Cytotoxic Activity of Human Her2neu Specific CD8 T cells by Comparing the Cr51 Release Assay to the xCELLigence System

Published on: August 8, 2012

感染破坏了T细胞的耐受性.

M Röcken1, J F Urban, E M Shevach

  • 1Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892.

Nature
|September 3, 1992
PubMed
概括
此摘要是机器生成的。

感染Nippostrongylus brasiliensis可以破坏由Staphylococcus enterotoxin B (SEB) 建立的T细胞耐受性. 这表明传染剂可能通过激活无性T细胞引发自身免疫性疾病.

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T Cells Capture Bacteria by Transinfection from Dendritic Cells
11:39

T Cells Capture Bacteria by Transinfection from Dendritic Cells

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An In Vitro Model of the Blood-brain Barrier Using Impedance Spectroscopy: A Focus on T Cell-endothelial Cell Interaction
10:17

An In Vitro Model of the Blood-brain Barrier Using Impedance Spectroscopy: A Focus on T Cell-endothelial Cell Interaction

Published on: December 8, 2016

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Last Updated: Jul 10, 2026

Determining Optimal Cytotoxic Activity of Human Her2neu Specific CD8 T cells by Comparing the Cr51 Release Assay to the xCELLigence System
11:31

Determining Optimal Cytotoxic Activity of Human Her2neu Specific CD8 T cells by Comparing the Cr51 Release Assay to the xCELLigence System

Published on: August 8, 2012

T Cells Capture Bacteria by Transinfection from Dendritic Cells
11:39

T Cells Capture Bacteria by Transinfection from Dendritic Cells

Published on: January 13, 2016

An In Vitro Model of the Blood-brain Barrier Using Impedance Spectroscopy: A Focus on T Cell-endothelial Cell Interaction
10:17

An In Vitro Model of the Blood-brain Barrier Using Impedance Spectroscopy: A Focus on T Cell-endothelial Cell Interaction

Published on: December 8, 2016

科学领域:

  • 免疫学 免疫学 免疫学
  • 这是一种自身免疫力.
  • 传染性疾病 传染性疾病

背景情况:

  • 通过克隆删除或无能性建立的T细胞耐受性,可以防止自身免疫反应.
  • 自主反应性T细胞通常被抑制以保持自我耐受性.

研究的目的:

  • 调查是否同时感染可以破坏已建立的T细胞耐受性.
  • 确定传染病原体可能绕过T细胞耐受性的机制.

主要方法:

  • 在小鼠中诱导T细胞耐受性,使用Staphylococcus enterotoxin B (SEB).
  • 在实验室中与SEB挑战耐受性T细胞,以评估细胞因子 (互白素-2,互白素-4) 的产生.
  • 用线虫Nippostrongylus brasiliensis感染耐受性小鼠,并在体内分析T细胞反应.

主要成果:

  • 在体外SEB挑战时,耐受SEB的T细胞没有产生互白素-2或-4 .
  • 在SEB耐受性小鼠中,N. brasiliensis感染导致了耐受性T细胞的正常扩张.
  • 感染还导致SEB反应性,交白素-4生成的T细胞在耐受性和正常动物中增加.

结论:

  • 尼波斯特朗吉勒斯巴西尼斯感染有效地规避了SEB诱导的T细胞耐受性.
  • 传染病原体可以通过其他途径激活无性T细胞来启动自身免疫.
  • 这项研究突出了自身免疫性疾病发展中的传染性触发因子的潜在机制.