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Isolation of Pulmonary Artery Smooth Muscle Cells from Neonatal Mice
Published on: October 20, 2013
吸入的氧化在新生儿持续性肺高血压的治疗中
J D Roberts1, D M Polaner, P Lang
1Department of Anesthesia, Massachusetts General Hospital, Boston 02114.
Lancet (London, England)
|October 3, 1992
概括
吸入的氧化 (NO) 迅速改善了新生儿持续性肺高血压 (PPHN) 的婴儿的氧化. 这种治疗是安全的,没有对血压或甲血球蛋白水平产生不良影响.
科学领域:
- 新生儿医学 新生儿医学
- 儿童心脏病学 儿童心脏病学
- 呼吸系统生理学 呼吸系统生理学
背景情况:
- 新生儿持续性肺高血压 (PPHN) 是一种严重的疾病,其特征是肺血管抵抗力升高.
- 氧化 (NO) 是已知的肺血管扩张剂在成人和动物,但它的影响新生儿PPHN需要进一步调查.
- 低氧症是PPHN的主要并发症,需要有效的治疗干预措施.
研究的目的:
- 评估吸入氧化 (NO) 的有效性和安全性,以改善患有PPHN的婴儿的全身氧化.
- 评估吸入NO对该患者群体系统血压和甲血球蛋白水平的影响.
主要方法:
- 六名被诊断患有PPHN的婴儿在高达80百万体积分 (ppmv) 的度下吸入NO,吸入氧气 (FiO2) 分数为0.9,长达30分钟.
- 通过先导和后导脉冲氧量计 (SpO2) 和动脉氧气张力来监测系统氧化.
- 密切监测全身血压和甲血球蛋白水平,以评估安全性.
主要成果:
- 在所有接受治疗的婴儿中,吸入NO的使用导致了先导 SpO2 的快速和显著增加.
- 在6名婴儿中,有5名婴儿表现出后导体SpO2和氧气张力的改善,这表明系统氧化增强.
- 在治疗期间没有观察到全身低血压或甲血球蛋白水平升高的情况,这表明安全性概况有利.
结论:
- 低水平的吸入氧化 (NO) 是一种有效的治疗策略,用于逆转患有PPHN的婴儿的低氧化症.
- 吸入NO在患有PPHN的新生儿中显示出有前途的安全性,没有显著的不良血液动力学或血液学影响.
- 这些发现支持使用吸入NO作为PPHN管理的有价值工具,改善氧化和潜在的临床结果.
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