气管中的血液动力学效应与静脉注射上腺素相比
1Department of Anaesthetics, Derriford Hospital, Plymouth, Devon, UK.
Lancet (London, England)
|October 10, 1992
概括
气管上腺素,即使是静脉注射量两倍的剂量,在心脏骤停患者的研究中也没有显著的血液动力学影响. 为了在复苏期间的有效性,可能需要更高的剂量.
科学领域:
- 心脏病学 心脏病学
- 紧急医疗 紧急医疗
- 药理学 药理学是指药理学的学科.
背景情况:
- 静脉内接入对于心肺复苏期间的药物输送至关重要.
- 气管内给药上腺素是当静脉注射无法获得时的替代方案.
- 目前的建议建议呼吸道剂量是静脉注射剂量的两倍.
研究的目的:
- 为了研究低剂量气管与静脉注射上腺素的血液动力学影响.
- 评估当前气管上腺素剂量建议的疗效.
主要方法:
- 一项随机交叉研究,涉及12名接受关节置换的麻醉患者.
- 患者分别通过静脉注射 (0.1微克/公斤) 和气管 (0.5微克/公斤) 接受上腺素.
- 对血液动力学参数进行监测,包括静脉压和心率.
主要成果:
- 静脉注射上腺素 (0.1微克/千克) 显著增加了静脉静脉压,平均为40.5毫米升,心率变化最小.
- 气管上腺素 (0.5微克/千克) 没有显著影响动脉压或心率.
- 低剂量的气管上腺素缺乏可测量的血液动力学影响.
结论:
- 推的气管上腺素剂量 (静脉注射剂量的两倍) 可能对治疗心脏骤停无效.
- 根据动物研究,可能需要更高的气管剂量,可能是静脉注射剂量的十倍.
- 需要进一步的研究,以建立有效的气管上腺素剂量用于复苏.
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