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Updated: Jun 23, 2026

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Changes in Mammary Gland Morphology and Breast Cancer Risk in Rats
Published on: October 17, 2010
有证据表明产前影响乳腺癌风险
A Ekbom1, D Trichopoulos, H O Adami
1Cancer Epidemiology Unit, Uppsala University Hospital, Sweden.
Lancet (London, England)
|October 24, 1992
概括
产前暴露于怀孕激素可能会影响乳腺癌风险. 诸如子前症 (妊娠并发症) 这样的疾病与较低的风险有关,而更大的胎儿尺寸显示出较高风险的趋势不显著.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 怀孕内源性雌激素的子宫内暴露被假设在乳腺癌病因学中起作用.
- 怀孕雌激素度的指标包括先兆子/子 (负相关) 和胎儿大小 (正相关).
研究的目的:
- 为了研究乳腺癌风险和妊娠性雌激素度指标之间的关联.
- 评估产前因素在乳腺癌发生中的作用.
主要方法:
- 一项嵌套病例控制研究使用乌普萨拉大学医院 (1874-1954) 的标准记录进行.
- 乳腺癌病例通过瑞典癌症登记 (1958-1990) 确定.
- 对458例病例和1197个匹配的对照进行了条件后勤回归分析.
主要成果:
- 孕前/孕后与乳腺癌风险有显著的反向关联 (比率 = 0.24,p = 0.01).
- 增加出生体重,出生长度和胎盘体重表明乳腺癌发病率的积极但不显著的趋势.
结论:
- 产前因素在乳腺癌发生过程中具有重要意义.
- 孕期雌激素度可能是导致因素,但不能排除其他产前或产周影响.
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