吸烟和体外受精率的降低
S K Rosevear1, D W Holt, T D Lee
1University of Bristol Department of Obstetrics and Gynaecology, St Michael's Hospital, UK.
在接受体外受精 (IVF) 的女性中,吸烟通过降低卵细胞受精率来显著降低生育能力. 卵泡液中的高丁氨酸水平表明吸烟暴露率较高,试管婴儿结果较差.
科学领域:
- 生殖医学 生殖医学
- 毒理学 毒理学 毒理学
- 通过体外受精进行体外受精
背景情况:
- 吸烟与女性生育能力的降低有关.
- 尼古丁代谢物科提宁是吸烟暴露的生物标志物.
研究的目的:
- 调查卵巢卵泡液中的科提宁水平与体外受精 (IVF) 成功之间的关系.
- 探索吸烟与不孕症相关的潜在机制.
主要方法:
- 从接受试管婴儿的妇女收集了卵巢卵泡液.
- 测量了毛囊液中的丁度.
- 卵细胞采集和受精率是根据科提宁水平进行分析的.
主要成果:
- 检测到的肉丁素 (>20 ng/ml) 的女性与检测不到的肉丁素 (72%) 的女性相比,卵细胞受精率 (44%) 显着较低.
- 平均受精率在高丁胺组为57%,而在低丁胺组为75% (p <0.05).
- 较高的哥提宁水平与IVF成功率的降低相关.
结论:
- 吸烟,以毛囊液科提宁为标志,在试管婴儿过程中对卵细胞受精产生负面影响.
- 应该建议不孕妇女,特别是那些接受试管婴儿的妇女,减少或戒烟.
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