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相关概念视频

NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...
What is Cancer?02:12

What is Cancer?

Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of patients who died from...
What is Cancer?02:12

What is Cancer?

Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of patients who died from...
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
Graves' Disease I: Introduction01:28

Graves' Disease I: Introduction

Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence in...

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相关实验视频

Updated: Jun 29, 2026

Anti-Nuclear Antibody Screening Using HEp-2 Cells
13:01

Anti-Nuclear Antibody Screening Using HEp-2 Cells

Published on: June 24, 2014

结核病是一种疾病.

Thomas R Frieden1, Timothy R Sterling, Sonal S Munsiff

  • 1New York City Department of Health and Mental Hygiene, New York, NY 10013, USA. tfrieden@health.nyc.gov

Lancet (London, England)
|September 19, 2003
PubMed
概括
此摘要是机器生成的。

结核病仍然是全球主要的杀手,特别是在发展中国家. 改进的诊断,像DOTS这样的治疗策略以及未来的疫苗对于控制至关重要.

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相关实验视频

Last Updated: Jun 29, 2026

Anti-Nuclear Antibody Screening Using HEp-2 Cells
13:01

Anti-Nuclear Antibody Screening Using HEp-2 Cells

Published on: June 24, 2014

Nuclei Isolation from Adult Mouse Kidney for Single-Nucleus RNA-Sequencing
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Nuclei Isolation from Adult Mouse Kidney for Single-Nucleus RNA-Sequencing

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科学领域:

  • 公共卫生 公共卫生
  • 传染性疾病 传染性疾病
  • 全球健康 全球健康

背景情况:

  • 结核病 (TB) 是全球第二大死亡原因,每年导致近200万人死亡.
  • 由于艾滋病毒,非洲的发病率正在上升,而在前苏联,由于社会经济因素和医疗保健的下降,发病率正在上升.
  • 诊断依赖于Mycobacterium结核菌培养,但快速唾液涂抹测试和分子方法至关重要.

研究的目的:

  • 审查全球结核病控制的现状.
  • 突出诊断,治疗和预防策略的挑战和进展.
  • 强调需要在疫苗开发和治疗系统方面继续努力.

主要方法:

  • 全球结核病发病率,死亡率和治疗数据的综述.
  • 对诊断技术的分析,包括培养,唾液涂抹和分子方法.
  • 对治疗策略的评估,重点是直接观察治疗,短期 (DOTS) 方法.

主要成果:

  • 超过95%的治愈率可以通过多药,六个月的治疗方案实现.
  • 直接观察治疗,短期 (DOTS) 是标准的护理,但全球只有三分之一的病例接受了它.
  • 在过去十年中,诊断和治疗方面取得了重大进展,但全球目标仍未实现.

结论:

  • 有效的结核病控制需要系统监测,改善病例检测和广泛采用DOTS.
  • 虽然新的疫苗正在开发中,但在未来几十年内,增强的治疗系统是必不可少的.
  • 全球控制结核病至关重要,以减少其对欠发达国家的影响,并减轻发达国家的风险.