长度评估前列腺特异性抗原水平的前列腺疾病和没有前列腺疾病的男性
H B Carter1, J D Pearson, E J Metter
1Department of Urology, Johns Hopkins University School of Medicine, Baltimore, MD.
JAMA
|April 22, 1992
概括
随着时间的推移,前列腺特异性抗原 (PSA) 水平的变化速度受到前列腺疾病的显著影响. 监测PSA变化可能有助于早期发现前列腺癌.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 老年学是一门学科.
- 在瘤学瘤学.
背景情况:
- 前列腺特异性抗原 (PSA) 水平可以随着年龄的增长而变化.
- 了解这些变化对于诊断前列腺疾病至关重要.
研究的目的:
- 为了评估PSA水平的纵向变化.
- 为了比较患有前列腺疾病和没有前列腺疾病的男性的PSA变化.
主要方法:
- 一项涉及巴尔的摩老龄化纵向研究的男性的病例控制研究.
- 在诊断前7-25年内分析血清PSA和雄激素水平.
- 参与者包括没有前列腺疾病,良性前列腺增生 (BPH) 和前列腺癌的男性.
主要成果:
- 与年龄相关的雄激素水平变化在各组之间没有差异.
- 随着对照对象的年龄,PSA水平没有显著变化.
- 前列腺癌的男性中,PSA水平的变化率显著高于前列腺癌的男性,其次是BPH,然后是对照 (P < .01).
- PSA 变化率将前列腺癌与 BPH 和高特异性 (90-100%) 的对照区分开来.
结论:
- 前列腺疾病是影响与年龄相关的PSA水平变化的重要因素.
- PSA 水平的变化速度可以作为前列腺癌发展的早期,敏感和特定标志物.
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