数字直肠检查对前列腺特异性抗原水平的影响
E D Crawford1, M J Schutz, S Clejan
1Division of Urology, University of Colorado Health Sciences Center, Denver.
JAMA
|April 22, 1992
概括
数字直肠检查 (DRE) 对大多数男性的前列腺特异抗原 (PSA) 水平的影响最小. 虽然PSA显著增加发生在初始水平非常高的男性中,但这些变化在治疗决策方面没有临床意义.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 临床化学 临床化学
背景情况:
- 前列腺特异性抗原 (PSA) 是前列腺癌查的关键生物标志物.
- 数字直肠检查 (DRE) 是前列腺癌查协议的常见组成部分.
- DRE对血清PSA水平的潜在影响需要仔细考虑.
研究的目的:
- 评估数字直肠检查 (DRE) 对血清前列腺特异抗原 (PSA) 水平的影响.
- 为了确定DRE诱导的PSA变化是否具有临床意义.
主要方法:
- 一项前性试验,涉及2754名40岁以上的健康男性接受前列腺癌查.
- 在DRE之前和之后测量血清PSA水平.
- 根据PSA水平的基线,患者被分为四组.
主要成果:
- 在男性中没有观察到具有统计意义的PSA变化,PSA初始水平为0.1-4μg/L和4.1-10μg/L.
- 在10.1-20μg/L组中,观察到PSA增加的趋势具有统计学意义.
- 在初始PSA>20μg/L的男性中发生了统计学上显著的PSA增加,但这些不是临床上显著的.
结论:
- 数字直肠检查没有产生血清PSA水平的临床重要变化.
- 在DRE后观察到的PSA变化不会影响患者的管理或治疗决策.
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