对于严重的,持续的,慢性尿道症的血酶
C E Grattan1, D M Francis, N G Slater
1St John's Institute of Dermatology, UMDS, London, UK.
Lancet (London, England)
|May 2, 1992
概括
慢性异常性疹 (CIU) 患者的基因组释放自身抗体是血合成的目标. 这种治疗在一些患者中提供了显著的症状缓解,这表明自身抗体在CIU病原发生中起着关键作用.
科学领域:
- 免疫学 免疫学 免疫学
- 皮肤病学 皮肤病学
- 过敏 过敏是一种过敏.
背景情况:
- 释放组胺的自身抗体与慢性异常性疹 (CIU) 有关.
- 严重的CIU病例通常在血清中表现出组胺释放活性.
研究的目的:
- 为了研究等离子体化在CIU重症患者的治疗效果.
- 探索基因组胺释放自身抗体在CIU病变发生中的作用.
主要方法:
- 在8名患有严重CIU和组胺释放血清活性的患者中进行了血合成.
- 皮肤测试对自身血清和皮内组胺的反应被评估为前和后的血分离.
- 测量血液细胞组胺和体外血清组胺释放活性.
主要成果:
- 症状缓解有所不同,2名患者的症状完全消失,2名患者的症状暂时缓解,2名患者的症状变化很小.
- 与交换前的血清相比,血清后的血清表现出皮肤测试反应的减少.
- 血液中的基因组胺水平增加,而体外血清基因组胺释放活性在术后降低.
结论:
- 血酶可以在严重的CIU中提供显著的,尽管是可变的,症状缓解.
- 这些发现支持了在慢性疹中释放基因组胺的自身抗体的病原学作用.
- 对CIU的自抗体向疗法的进一步研究是有必要的.
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