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Updated: Jul 7, 2026

Assaying β-amyloid Toxicity using a Transgenic C. elegans Model
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Assaying β-amyloid Toxicity using a Transgenic C. elegans Model

Published on: October 9, 2010

在老鼠中,细胞适应吗啡.

A E TAKEMORI

    Science (New York, N.Y.)
    |March 31, 1961
    PubMed
    概括
    此摘要是机器生成的。

    吗啡在对照大鼠中抑制了脑细胞呼吸,但在长期暴露于吗啡的老鼠中没有. 这表明细胞对吗啡的适应反映了整个动物的耐受性.

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    科学领域:

    • 神经药理学神经药理学
    • 细胞生物学 细胞生物学
    • 生理学 生理学 生理学

    背景情况:

    • 吗啡是一种强大的阿片类止痛药,已知对中枢神经系统有影响.
    • 长期服用吗啡会导致动物和人类产生耐受性和身体依赖性.

    研究的目的:

    • 为了研究吗啡对大鼠大脑细胞呼吸的影响.
    • 为了确定细胞适应吗啡是否发生在脑组织呼吸的水平.

    主要方法:

    • 使用KCl刺激的大脑皮质切片从对照和慢性吗啡治疗的老鼠.
    • 在这些脑部切片中测量了细胞呼吸的速率.

    主要成果:

    • 吗啡显著抑制了对照大鼠皮层切片的呼吸.
    • 长期暴露于吗啡的老鼠皮层切片的呼吸不受药物的影响.

    结论:

    • 在大鼠大脑组织中表现出细胞水平对吗啡的适应.
    • 这种细胞适应与整个动物对吗啡的适应 (耐受性) 相同时发生.
    关键词:
    大脑皮层/药理学吗啡 / 药理学

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