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相关概念视频

Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

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相关实验视频

Updated: Jul 6, 2026

Changes in Mammary Gland Morphology and Breast Cancer Risk in Rats
09:36

Changes in Mammary Gland Morphology and Breast Cancer Risk in Rats

Published on: October 16, 2010

激素对小鼠乳腺癌的影响的性质.

H A BERN

    Science (New York, N.Y.)
    |April 8, 1960
    PubMed
    概括
    此摘要是机器生成的。

    激素可能允许,而不是诱导乳腺瘤,通过支持腺体发育和增生性病变. 遗传敏感性对 somatotropin 可能解释遗传激素影响乳腺癌的发展.

    关键词:
    乳腺新增体/实验性 乳腺新增体卡尔基诺玛,达克特/实验性的荷尔蒙/药理学 这些

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    Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer
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    Last Updated: Jul 6, 2026

    Changes in Mammary Gland Morphology and Breast Cancer Risk in Rats
    09:36

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    Published on: October 16, 2010

    The Use of Mouse Mammary Tumor Cells in an In Vitro Invasion Assay as a Measure of Oncogenic Cell Behavior
    08:12

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    Published on: June 12, 2019

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    科学领域:

    • 内分泌学 在内分泌学.
    • 在瘤学瘤学.
    • 遗传学 是一个遗传学.

    背景情况:

    • 激素在乳腺发育和癌症中的作用是复杂的.
    • 以前的研究表明,荷尔蒙积极诱导瘤形成.

    研究的目的:

    • 为了研究激素在乳腺瘤发生中的精确作用.
    • 探索乳腺癌中"遗传激素影响"的概念.

    主要方法:

    • 对激素对乳腺组织的影响的分析.
    • 研究与激素敏感性相关的遗传因素.

    主要成果:

    • 荷尔蒙似乎在乳腺瘤发生过程中起到了允许的,而不是诱导的作用.
    • 支持正常发育的激素可以导致癌前病变.
    • 维持高可塑性病变的荷尔蒙可以导致瘤的出现.
    • 遗传上对 somatotropin 的敏感性可能是遗传激素的影响的基础.

    结论:

    • 激素在乳腺瘤发生中的影响是宽容的,促进了进展,而不是启动它.
    • 对索马托的遗传倾向可能是与激素相关的乳腺癌风险的一个关键因素.