通过蛋白激酶A对外纠正Cl-通道的缺陷调节,通过插入CFTR进行纠正

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Updated: Jul 7, 2026

In Vitro Analysis of PDZ-dependent CFTR Macromolecular Signaling Complexes
10:05

In Vitro Analysis of PDZ-dependent CFTR Macromolecular Signaling Complexes

Published on: August 13, 2012

M Egan1, T Flotte, S Afione

  • 1Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.

Nature
|August 13, 1992
PubMed
概括

使用腺相关病毒载体的囊性纤维化 (CF) 基因疗法恢复了CF支气管细胞中的化物分泌. 这纠正了CFTR功能,并重新建立了外向纠正化物通道,使它们与CF有关.

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