在心脏移植后,运动期间左心室放松的加速不足
W J Paulus1, J G Bronzwaer, H Felice
1Cardiovascular Center, O.L.V. Ziekenhuis, Aalst, Belgium.
Circulation
|October 1, 1992
概括
与健康个体相比,心脏移植接受者在运动期间显示左心室放松受损. 这种减轻的放松反应,以左心室压力衰减的时间常数来衡量,会影响移植后的舒张功能.
科学领域:
- 心脏病学 心脏病学
- 移植医学 移植医学
- 身体生理学 身体生理学
背景情况:
- 运动增加了心脏移植后的左心室填充压力,这归因于心率反应和变化的异位移植属性.
- 左心室放松对这些压力变化的具体影响仍未得到充分研究.
研究的目的:
- 为了研究心脏移植接受者对运动的左心室放松反应.
- 将这种反应与健康个体的反应进行比较.
- 探索β-上腺体受体刺激,后负载减轻和增加对全移植放松的影响.
主要方法:
- 在27名移植接受者和9名对照者中,尖端微观仪记录了左心室压力和血液动力学评估.
- 使用了运动压力测试,多布胺输液,酸输液和后极星静态强化.
- 使用左心室压力衰减 (T) 的时间常数量化左心室放松率.
主要成果:
- 与对照组相比 (42±7至34±6毫秒),运动导致移植受体的T缩短较小 (43±6至40±8毫秒).
- 与对照组不同的是,移植受体在运动期间表现出左心室最低透气压的升高,而对照组则没有.
- 整体移植放松显示了对多布胺,尼托普鲁塞德和后外静态增强的可变反应,其中一些表明放松受损.
结论:
- 与健康对照人群相比,心脏移植接受者在运动期间显示左心室放松减弱.
- 减弱的放松反应可能会导致移植后填充压力升高.
- 药理干预和强化揭示了异种移植透气功能的复杂变化.
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