阿普罗丁宁可以防止心肺旁路诱导的血小板功能障碍. 一个扫描电子显微镜研究研究
1Department of Cardiac Surgery and Epidemiology, Chaim Sheba Medical Center, Tel Hashomer, Israel.
Circulation
|November 1, 1992
概括
在心肺绕道术期间服用阿普罗丁尼可显著保持血小板功能并减少血液损失. 与低剂量或安慰剂相比,高剂量的阿波丁因显示出优越的血小板保护和改善的术后血静.
科学领域:
- 心血管外科心血管外科
- 血液学 血液学 血液学
- 药理学 药理学 是一个学科.
背景情况:
- 众所周知,阿普罗丁因在体外循环过程中减少血液损失并改善血小板功能.
- 血小板功能障碍是心肺旁路手术期间的一个问题.
研究的目的:
- 为了评估阿普罗丁因在心肺旁路术期间对血小板功能的保护作用.
- 为了比较高剂量连续阿普罗丁尼与低剂量玻尿酸阿普罗丁尼和安慰剂的疗效.
主要方法:
- 50名接受心肺旁路术的患者被随机分为三个组:高剂量阿普罗丁宁,低剂量阿普罗丁宁和安慰剂.
- 使用扫描电子显微镜评估了血小板聚合,并从1到4进行分级.
- 术后测量了血液损失,血小板计数,输血红细胞单位和同源血制品.
主要成果:
- 与低剂量 (B组,平均等级2.9) 和安慰剂 (C组,平均等级1.4) 相比,高剂量的阿波丁素 (A组) 维持了显著更好的血小板聚合 (平均等级3.4).
- 组A的血液流失 (395毫升) 比B组 (488毫升) 和C组 (780毫升) 显著减少.
- 与安慰剂组相比,接受aprotinin的患者需要较少的红细胞单位和同源血制品.
结论:
- 在心肺绕行术期间,阿普罗丁因有效地保持了血小板功能.
- 高剂量阿普罗丁的使用会改善术后血静,并减少输血需求.
- 在心脏外科手术中,阿普罗丁因对缓解血小板功能障碍和相关出血并发症有好处.
相关概念视频
01:27Transducer Mechanism: Enzyme-Linked Receptors
Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
Major types that are helpful drug targets include:
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
01:20Imaging Studies for Cardiovascular System III: X-Ray
The most common cardiovascular diagnostic test is an X-ray. It produces images of the heart, blood vessels, and adjacent structures.
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
01:30Acute Coronary Syndrome III: Diagnostic Studies
Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
01:30Dysrhythmias V: Evaluating Dysrhythmias
Dysrhythmias, also known as arrhythmias, are disturbances in the heart's rhythm that range from benign to life-threatening. A thorough evaluation is crucial for appropriate management and involves a comprehensive medical history, physical examination, and various diagnostic tests.Medical HistorySymptoms: Collect detailed information on palpitations, dizziness, syncope, chest pain, and fatigue. Note their onset, frequency, and triggers.Previous Cardiac Issues: Document any history of heart...