在心肺绕道术期间监测阿普罗丁宁和肝素
1Department of Research Haematology, Harefield Hospital, Middlesex, England.
Circulation
|November 1, 1992
概括
高剂量的阿波宁可独立于肝素延长激活凝血时间 (ACT) 和激活部分血栓形成时间 (APTT). 在心肺绕道术期间使用阿普罗丁尼时,在750秒内保持ACT,以准确监测肝素.
科学领域:
- 麻醉学 麻醉学
- 心血管外科心血管外科
- 血液学 血液学 血液学
背景情况:
- 在心肺绕道术 (CPB) 期间使用高剂量的阿波丁素可以延长激活凝血时间 (ACT).
- 在CPB期间,ACT是监测肝化的关键参数.
- 阿普罗丁因对ACT监测的影响需要澄清安全的CPB程序.
研究的目的:
- 建立指导方针,通过ACT监测肝素水平,当APROTININ在CPB期间被管理.
- 调查阿普罗丁宁对凝血试验的独立作用.
主要方法:
- 阿普罗丁因被添加到健康对照组和CPB患者的肝素化血液样本中.
- 测量了活性凝血时间 (ACT) 和活性部分血栓形成时间 (APTT).
- 评估了前血时间 (PT),以确定aprotinin的特异性.
主要成果:
- 阿普罗丁因显示了ACT和APTT的剂量依赖延长.
- 这种效应不论活性剂或氨酸的存在都被观察到.
- 阿普罗丁因没有影响前热血素时间 (PT).
结论:
- 阿普罗丁因延长了ACT和APTT,独立于肝素的抗凝效应.
- 为了确保在CPB中使用高剂量阿普罗丁素的充足的肝素化,ACT值应超过750秒.
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