转化细胞激活信号的氨酸含有基因也决定了通过IgG的III型受体的内部化和抗原呈现
S Amigorena1, J Salamero, J Davoust
1Laboratoire d'Immunologie Cellulaire et Clinique, INSERM U255, Institut Curie, Paris, France.
Nature
|July 23, 1992
概括
这项研究揭示了Fc马RIII受体的马子单元对联体内化至关重要,并提高了抗原呈现效率. 在玛链中的氨酸残留物.
科学领域:
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
- 分子生物学分子生物学
背景情况:
- 多重体受体,如Fc玛RII和Fc西隆RI,具有专门的子单元,用于连接体结合和信号传导.
- 巨细胞利用Fc玛RIIα和玛子单元进行抗原吸收,处理和呈现给T淋巴细胞.
- Fc玛RIII受体在免疫反应中发挥作用,特别是在抗原呈现细胞中.
研究的目的:
- 研究Fc玛RIII子单元在配体内化和抗原呈现中的作用.
- 确定负责有效免疫复合体吸收和呈现的特定子单元及其域.
- 阐明涉及Fc马RIII马子单元在受体介导内细胞突变中的信号机制.
主要方法:
- 鼠类Fc玛RIII细胞转化为Fc玛R阴性B淋巴瘤细胞.
- 使用化学分子来剖析Fc马RIIIα和马子单元的功能.
- 在玛链的细胞质域内对氨酸残留物的突变分析.
主要成果:
- Fc玛RIII调解了快速的连接体内化,并增强了IgG复合抗原的抗原呈现.
- 带结合的α链的细胞质域不需要内部化或呈现.
- 玛子单元是必不可少的,其细胞质域中的特定氨酸残留物对免疫复合物的内部化和抗原呈现至关重要.
结论:
- Fc马RIII马子单元含有用于受体内化的信号.
- 在玛链的细胞质域中的氨酸残留物对于有效的内化和抗原呈现至关重要.
- 关联受体链,特别是它们的氨酸含有基因,对于多重体受体内部化至关重要,而不仅仅是细胞激活.
相关概念视频
Antibody Structure
Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
Internal Receptors
Many cellular signals are hydrophilic and therefore cannot pass through the plasma membrane. However, small or hydrophobic signaling molecules can cross the hydrophobic core of the plasma membrane and bind to internal, or intracellular, receptors that reside within the cell. Many mammalian steroid hormones use this mechanism of cell signaling, as does nitric oxide (NO) gas.
Transcytosis of IgG
Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
Antigens Involved in Adaptive Immunity
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.
Diversity of Antigen Receptors
Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
B Cell Activation and Differentiation
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...


