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Updated: Jul 15, 2026

Differentiation, Maintenance, and Analysis of Human Retinal Pigment Epithelium Cells: A Disease-in-a-dish Model for BEST1 Mutations
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通过人类环林的异位表达来调节视网膜母细胞瘤蛋白功能

P W Hinds1, S Mittnacht, V Dulic

  • 1Whitehead Institute, Cambridge, Massachusetts 02142.

Cell
|September 18, 1992
PubMed
概括

视网母细胞瘤蛋白 (pRb) 调节细胞增殖. G1和S相环林通过促进其酸化来克服pRb抑制,这表明它在细胞循环控制中起着关键作用.

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The Tumor Microenvironment02:17

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...