在慢性大血管血栓栓塞性肺高血压中,内源性纤维溶解系统
M A Olman1, J J Marsh, I M Lang
1Division of Pulmonary and Critical Care Medicine, University of California, San Diego.
Circulation
|October 1, 1992
概括
慢性血栓栓塞性肺高血压 (CTEPH) 涉及纤维素分解受损. 虽然组织型等离子体激活剂 (t-PA) 和等离子体激活剂抑制剂-1 (PAI-1) 水平在CTEPH患者中发生变化,但它们的活性不能完全解释这种情况.
科学领域:
- 心血管研究研究心血管研究
- 血液学 血液学 血液学
- 肺部医学 肺部医学
背景情况:
- 慢性血栓栓塞性肺高血压 (CTEPH) 是由肺动脉高血压的特征,由于中心肺动脉中有组织的血栓.
- 在CTEPH中血栓溶解不良背后的确切机制尚不清楚.
- 这项研究研究了血纤维解在CTEPH病变发生中的作用.
研究的目的:
- 评估CTEPH患者血纤维解质的主要决定因素.
- 在CTEPH患者中量化组织类型等离子体激活剂 (t-PA) 和等离子体激活剂抑制剂-1 (PAI-1) 的免疫和功能水平.
主要方法:
- 从32名CTEPH患者和年龄匹配对照中量化t-PA和PAI-1抗原和血小板贫血 (PPP) 的活性.
- 实验诱导静脉封闭,以评估t-PA和PAI-1的反应.
- 免疫沉和纤维素自拍以分析t-PA/PAI-1复合体.
主要成果:
- 与对照组相比,CTEPH患者表现出较高的t-PA和PAI-1抗原基底水平.
- 两组之间没有发现t-PA和PAI-1的酶活性有显著差异.
- 在静脉封闭后,CTEPH患者的t-PA抗原和PAI活性显著增加.
- 在一些CTEPH患者中,基底t-PA抗原升高主要与PAI-1复合.
结论:
- 纤维分析系统的异常,特别是改变的t-PA和PAI-1水平,存在于CTEPH中.
- 既没有高的静止血PAI-1活性,也没有对静脉封闭的麻木的t-PA反应完全解释了CTEPH的病因.
- 这些发现表明CTEPH中纤维解质因子的复杂相互作用,t-PA可能与PAI-1结合.
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