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Cardiac Stress Test Induced by Dobutamine and Monitored by Cardiac Catheterization in Mice

Cardiac Stress Test Induced by Dobutamine and Monitored by Cardiac Catheterization in Mice

Published on: February 10, 2013

皮莫本丹在狗左心室中的机械能量效应. 与 dobutamine 的比较

K Hata¹, Y Goto, S Futaki

¹Department of Cardiovascular Dynamics, National Cardiovascular Center, Osaka, Japan.

|October 1, 1992

概括

皮莫本丹和多布胺类似地改善了心脏收缩性. 皮莫本丹提供了稍微更好的收缩经济和血管扩张,但这两种药物都没有降低收缩的氧气成本.

科学领域:

心脏病学心脏病学
药理学药理学是指药理学的学科.
生理学生理学生理学

背景情况:

皮莫本丹增加了收缩蛋白质的敏感性.
多布他胺通过其他机制增强了心室收缩性.
比较心肌氧消耗量 (VO2) 的 pimobendan 和 dobutamine 是至关重要的.

研究的目的:

为了比较pimobendan和dobutamine对左心室收缩和能量的影响.
测试该假设,皮莫本丹的敏化作用降低心肌氧消耗量 (VO2).

主要方法:

使用的切除,交叉循环,不失败的狗心.
测量VO2,Emax (收缩性指数),PVA (心压-体积面积) 和FTI (力-时间积分).
分析了VO2-PVA关系以确定收缩效率和经济性.

主要成果:

这两种药物都比较强化了Emax.
皮莫本丹显示了14%的更大的收缩经济 (p<0.05).
收缩效率和收缩的氧气成本是相似的; pimobendan 具有更大的冠状动脉血管扩张.

结论:

皮莫本丹和多布胺表现出类似的机能效应.
皮莫本丹提供略微增强的收缩经济和冠状动脉血管扩张.
皮莫本丹对的敏感化作用并没有降低收缩性的氧气成本.

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