相关实验视频
Updated: Jul 22, 2026
11:49
Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation
Published on: May 2, 2013
概括
放射性破伤风毒素在小鼠免疫细胞中持续了9个月. 在再次接触抗原后,这些标记的细胞显示出显著的细胞变化,并吸引了其他免疫细胞.
科学领域:
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
- 毒理学 毒理学 毒理学
背景情况:
- 毒素是一种由Clostridium tetani产生的强有力的神经毒素.
- 了解毒素的长期命运和细胞相互作用对于疫苗开发和免疫学至关重要.
- 免疫细胞对毒素的反应可能涉及抗原呈现和细胞贩运.
研究的目的:
- 为了研究长期毒素在免疫细胞中的持久性.
- 描述在抗原重新挑战时与毒素标记细胞相关的细胞变化和免疫细胞招募.
主要方法:
- 用疹毒素对小鼠进行免疫接种.
- 在免疫小鼠中注射三性破伤风毒素.
- 长度观察淋巴细胞和巨细胞中的放射性.
- 在二次抗原挑战后细胞形态和免疫细胞透的组织学检查.
主要成果:
- 在注射后长达9个月的时间里,在淋巴细胞和巨细胞中检测到来自三性破伤风毒素的放射性.
- 被标记的细胞表现出显著的真空化.
- 用特定抗原的再注射导致了对标记细胞的氨基和淋巴细胞的吸引.
结论:
- 免疫细胞,特别是淋巴细胞和巨细胞,可以长时间保留结毒素的成分.
- 与毒素相关的细胞物质的存在可以在随后的抗原暴露时触发局部免疫反应.
- 这些发现突出了免疫细胞和毒素成分之间的长期相互作用,这对了解免疫记忆和炎症反应有意义.
相关概念视频
01:40Cell-mediated Immune Responses
Overview
00:42Cross-reactivity
Overview
01:23Cells of the Adaptive Immune Response
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
01:26Antigens Involved in Adaptive Immunity
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.