一个基于人口的双胞胎研究,对女性饮酒的研究
K S Kendler1, A C Heath, M C Neale
1Department of Psychiatry, Medical College of Virginia/Virginia Commonwealth University, Richmond 23298-0710.
JAMA
|October 14, 1992
概括
遗传因素对女性的酒有很大影响,遗传性估计在50-60%之间. 这凸显了将女性纳入饮酒障碍遗传易感性研究的重要性.
科学领域:
- 精神病学是一个精神病学.
- 遗传学 是一个遗传学.
- 流行病学 流行病学
背景情况:
- 酒是一种复杂的疾病,具有多因素的原因.
- 了解女性对酒的遗传贡献对于有针对性的干预至关重要.
研究的目的:
- 研究遗传因素在妇女中酒的发展中的作用.
- 估计女性双胞胎队列中对酒的责任的遗传性.
主要方法:
- 利用了来自弗吉尼亚州双胞胎登记处的1030对女性双胞胎的基于人口的样本.
- 进行了个人结构化精神病学采访,对双胞胎共生盲目.
- 根据DSM-III-R标准,应用了三种不同的酒精的终身流行定义.
主要成果:
- 在所有定义中,与双胞胎双胞胎 (DZ) 相比,单胞胎 (MZ) 双胞胎中,酒症的试验一致率始终较高.
- 多因素值模型表明,女性对酒的责任遗传率在50%至60%之间.
结论:
- 研究结果强烈支持遗传因素在女性酒的病因学中起着重要作用.
- 强调有必要将女性参与者纳入旨在了解遗传易受酒症影响的研究.
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