在家族上皮卵巢癌发病时的年龄
C I Amos1, G L Shaw, M A Tucker
1National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Md.
JAMA
|October 14, 1992
概括
患有卵巢癌的一个亲属的女性面临更高的风险,但没有更早的发病. 然而,那些患有多个受影响的亲属的人的发病年龄要早得多,这表明预防性卵巢切除可能是有益的.
科学领域:
- 在瘤学瘤学.
- 遗传学 是一个遗传学.
- 流行病学 流行病学
背景情况:
- 卵巢癌的风险受家庭病史的影响.
- 了解亲属的特定年龄风险和发病模式对于风险评估和管理至关重要.
研究的目的:
- 确定卵巢癌患者一级亲属的特定年龄卵巢癌风险.
- 为了比较女性的发病年龄,一个受影响的亲属与多个受影响的亲属相比.
主要方法:
- 从癌症和类固醇激素 (CASH) 研究中重新分析数据.
- 从华盛顿特区的病例对照研究中,在有和没有受影响的亲属的妇女中,发病年龄的比较.
- 从国家癌症研究所 (NCI) 对具有广泛家族病史的妇女的分析.
主要成果:
- 卵巢癌患者的一级亲属患卵巢癌的风险增加,特别是在年龄较大时.
- 在DC研究中,患有和没有受影响的亲属的女性的发病平均年龄相似.
- 与普通人口 (59岁) 相比,患有多名受影响亲属的女性 (NCI研究) 患病时年龄明显较小 (47岁),17%的人在40岁时被诊断出患病.
结论:
- 单一受影响的一级亲属会增加卵巢癌的风险,但不会增加发病年龄.
- 多个受影响的亲属与明显较早的发病年龄有关.
- 预防性卵巢切除术对于有多位受影响亲属的妇女来说可能是一个合理的考虑,因为她们患早期疾病的风险增加.
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