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相关概念视频

Mechanisms of Retrovirus-induced Cancers01:51

Mechanisms of Retrovirus-induced Cancers

Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
Mechanisms of Retrovirus-induced Cancers01:51

Mechanisms of Retrovirus-induced Cancers

Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
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Cytomegalovirus Disease

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相关实验视频

Updated: Jun 19, 2026

High-Efficiency Transduction of Liver Cancer Cells by Recombinant Adeno-Associated Virus Serotype 3 Vectors
19:02

High-Efficiency Transduction of Liver Cancer Cells by Recombinant Adeno-Associated Virus Serotype 3 Vectors

Published on: March 22, 2011

人类ADENOVIRUS TYPE 12在子中的瘤效应.

Y YABE, L SAMPER, E BRYAN

    Science (New York, N.Y.)
    |January 3, 1964
    PubMed
    概括
    此摘要是机器生成的。

    人类腺病毒12型诱导新生小鼠未分化的恶性瘤,特别是C(3) H(f) /G(8) 菌株. 观察到瘤的发展,尽管与子相比,瘤的发展速度较低.

    关键词:
    亚德诺病毒的病毒.实验室研究实验室研究美国的米饭.新等离子体的病因学新质体,实验性的新质体

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    Handling of the Cotton Rat in Studies for the Pre-clinical Evaluation of Oncolytic Viruses
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    Transarterial Administration of Oncolytic Viruses for Locoregional Therapy of Orthotopic HCC in Rats
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    Transarterial Administration of Oncolytic Viruses for Locoregional Therapy of Orthotopic HCC in Rats

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    Published on: March 22, 2011

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    06:13

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    科学领域:

    • 在瘤学瘤学.
    • 病毒学 病毒学
    • 遗传学 遗传学 是一个

    背景情况:

    • 人类腺病毒12型 (HAdV-12) 已知会诱导子的瘤.
    • 在不同的小鼠菌株中,HAdV-12的致癌潜力并未得到很好的描述.

    研究的目的:

    • 在不同遗传背景的新生小鼠中研究12型人类腺病毒的致癌潜力.
    • 为了比较小鼠中的瘤诱导与子中观察到的瘤诱导.

    主要方法:

    • 新生小鼠的C{3) H{f) /G{8),DBA{f) 和A{f) 菌株被注射了人类腺病毒12型.
    • 监测瘤的发展,并分析诱导的瘤粗略和组织学.

    主要成果:

    • 在C(3) H(f) /G(8) 菌株小鼠的注射部位诱导了未分化的恶性瘤.
    • 在DBA (f) 或A (f) 株的小鼠中没有观察到瘤.
    • 诱导的瘤在组织学上与子中发现的瘤相似,但在小鼠中发生的比例较低.

    结论:

    • 鼠标菌株C(3) H(f) /G(8) 易受12型腺病毒诱导的瘤发生.
    • 鼠标菌株遗传学在腺病毒诱导的瘤形成中发挥着关键作用.
    • 虽然类似于子诱导的瘤,但HAdV-12的致癌性在敏感的小鼠菌株中效率较低.