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相关概念视频

Toxicity Testing in Animals01:23

Toxicity Testing in Animals

Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...

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相关实验视频

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Measuring Progressive Neurological Disability in a Mouse Model of Multiple Sclerosis
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Published on: November 14, 2016

用DDT中毒:临床症状与大鼠大脑中的度之间的关系

W E DALE, T B GAINES, W J HAYES

    Science (New York, N.Y.)
    |December 13, 1963
    PubMed
    概括

    暴露于DDT的老鼠中毒症状的严重程度与大脑DDT度直接相关. 致命的大脑度是一致的,无论是从单一的大剂量还是多个较小剂量.

    科学领域:

    • 毒理学 毒理学 毒理学
    • 神经科学是一个神经科学.
    • 环境科学 环境科学

    背景情况:

    • DDT (二二三乙) 是一种持久性有机污染物,具有已知的神经毒性作用.
    • 了解DDT毒性的剂量反应关系对于风险评估至关重要.

    研究的目的:

    • 研究大鼠DDT脑度与中毒严重程度之间的相关性.
    • 为了确定急性高剂量和慢性低剂量暴露是否会导致DDT的致命脑度相似.

    主要方法:

    • 给老鼠注射了单次高剂量的DDT.
    • 对大脑组织进行了分析,以确定DDT度.
    • 记录了中毒和死亡的临床迹象.

    主要成果:

    • 观察到DDT脑度与中毒症状严重程度之间存在直接的比例.
    • 单次大剂量后与死亡相关的大脑DDT度与多次小剂量后观察到的度相似.

    结论:

    • 大脑DDT度是急性和慢性毒性的关键决定因素.
    • 无论用什么剂量方案,DDT的神经毒性作用都取决于大脑中的度.
    关键词:
    我们的大脑大脑.这就是DDT DDT.组织细胞化学 组织细胞化学它们是老鼠.毒理学报告 毒理学报告

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