血球溶解性和阿尔法链结构在两种内科小鼠菌株之间的交叉中
Science (New York, N.Y.)
|January 17, 1964
概括
在小鼠中,血红蛋白溶解度由α链结构等位素控制,分离为孟德尔单元. 这项研究绘制了阿尔法链位点,不包括与几种小鼠遗传标记的联系.
科学领域:
- 遗传学 是一个遗传学.
- 分子生物学分子生物学
- 生物化学 生物化学
背景情况:
- 在老鼠菌株之间存在血红蛋白溶解度的差异.
- 溶解度似乎与α链结构有关.
研究的目的:
- 在小鼠中确定血红蛋白溶解性的遗传基础.
- 为了绘制阿尔法链位点及其与已知的遗传标记物的联系.
- 开发对α链和可溶性的简化选方法.
主要方法:
- 进行了不同血红蛋白溶解度的小鼠菌株之间的遗传交叉.
- 分析了可溶性分离作为孟德尔单位.
- 选的α链和遗传标记.
- 使用简化方法进行和溶性选.
主要成果:
- 血红蛋白溶解度分离为孟德尔的单位.
- 溶解度是由控制α链结构的等位体决定的.
- 阿尔法链位点与III,IV,XI,XIII和XVI链接组的标记物没有密切的联系.
结论:
- 鼠标血红蛋白溶解度的主要决定因素是α链结构.
- 阿尔法链位点与几种已建立的小鼠遗传标记没有密切联系.
- 简化查方法有助于进一步研究血红蛋白变异.
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