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Induction of Graft-versus-host Disease and In Vivo T Cell Monitoring Using an MHC-matched Murine Model
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Published on: August 29, 2012

辐射诱导的小鼠白血病:一个额外的和一个标志性染色体的持续发生.

N WALD, A C UPTON, V K JENKINS

    Science (New York, N.Y.)
    |February 21, 1964
    PubMed
    概括

    在小鼠中X辐射诱导的粒细胞白血病. 白血病小鼠的染色体异常表明这些变化的病毒原因,在注射白血病细胞或无细胞提取物后观察到.

    科学领域:

    • 在瘤学瘤学.
    • 病毒学 病毒学
    • 遗传学 是一个遗传学.

    背景情况:

    • 射线照射可以诱导小鼠中的粒细胞白血病.
    • 白血病可以在小鼠之间连续传播.
    • 染色体异常与癌症的发展有关.

    研究的目的:

    • 为了研究小鼠辐射诱导的粒细胞白血病的潜在病毒病因.
    • 为了识别与白血病传播相关的细胞变化.

    主要方法:

    • 在小鼠中通过X辐射诱导颗粒细胞白血病.
    • 使用白血病脏细胞和无细胞超离心器的白血病的连续传播.
    • 分析骨髓细胞的染色体异常.

    主要成果:

    • 诱导型粒细胞白血病的连续传播在RF/Up小鼠中取得了成功.
    • 白血病小鼠在骨髓细胞中始终表现出额外的染色体和形态异常的染色体.
    • 这些染色体变化在小鼠中观察到,小鼠注射了白血病细胞或无细胞提取物.

    结论:

    • 传染性白血病中特定染色体异常的持续存在表明了共同的潜在原因.
    关键词:
    染色体异常 染色体异常实验室研究实验室研究白血病,辐射诱导的美国的米饭.

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  • 这些发现强烈表明,病毒是诱导白血病和观察到的染色体变化的原因.