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相关概念视频

Neurulation01:30

Neurulation

Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the anterior...
Cell Migration01:09

Cell Migration

Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
Cell Migration01:19

Cell Migration

Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.

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相关实验视频

Updated: Jun 20, 2026

Migratory Behavior of Cells Generated in Ganglionic Eminence Cultures
06:34

Migratory Behavior of Cells Generated in Ganglionic Eminence Cultures

Published on: April 21, 2011

发育中的大脑皮层中的多种迁移途径.

N A O'Rourke1, M E Dailey, S J Smith

  • 1Department of Biological Sciences, Stanford University, CA 94305.

Science (New York, N.Y.)
|October 9, 1992
PubMed
概括
此摘要是机器生成的。

在哺乳动物大脑皮层发育期间,年轻的神经元向外迁移. 一些神经元沿着质纤维辐射迁移,而另一些神经元则沿直角迁移,可能有助于神经元的分散.

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Ex Utero Electroporation and Organotypic Slice Cultures of Embryonic Mouse Brains for Live-Imaging of Migrating GABAergic Interneurons
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Ex Utero Electroporation and Organotypic Slice Cultures of Embryonic Mouse Brains for Live-Imaging of Migrating GABAergic Interneurons

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Time-Lapse Imaging of Migrating Neurons and Glial Progenitors in Embryonic Mouse Brain Slices
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Time-Lapse Imaging of Migrating Neurons and Glial Progenitors in Embryonic Mouse Brain Slices

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科学领域:

  • 神经科学是一个神经科学.
  • 发展生物学 发展生物学
  • 细胞生物学 细胞生物学

背景情况:

  • 在哺乳动物大脑皮层发育过程中,新形成的神经元从心室区域迁移到皮层板,以建立成人皮层.
  • 神经元迁移是形成大脑复杂神经回路的基本过程.

研究的目的:

  • 直接观察哺乳动物大脑皮层发育中的活切片中迁移神经元的动态行为.
  • 在早期发育过程中调查皮质神经元的迁移途径和行为.

主要方法:

  • 利用时差共聚焦显微镜实时可视化细胞动态.
  • 使用哺乳动物发育中的大脑皮层的活组织切片进行观察.

主要成果:

  • 大多数迁移神经元遵循辐射路径,与沿辐射质纤维的迁移保持一致.
  • 神经元的一个子集在中间区域内表现出直角迁移,偏离辐射路径.
  • 观察到的直角迁移表明,克隆相关神经元的触角分散机制.

结论:

  • 皮层神经元沿辐射质纤维迁移,但一个不同的群体也在直角迁移.
  • 正角迁移可能在皮层神经元的触角分散和空间组织中发挥重要作用.
  • 了解这些迁移模式对于理解皮质发育和潜在的发育障碍至关重要.