在缺乏阿波利波蛋白E的小鼠中,自发性高胆固醇血清和动脉病变
S H Zhang1, R L Reddick, J A Piedrahita
1Department of Pathology, University of North Carolina, Chapel Hill 27599-7525.
Science (New York, N.Y.)
|October 16, 1992
概括
缺乏阿波利波蛋白E (apoE) 的小鼠患有高胆固醇和自发动脉硬化,显示动脉病变和冠状动脉封闭. 这些apoE缺乏的小鼠作为一种有价值的模型来研究动脉样硬化发展.
科学领域:
- 心血管生物学 心血管生物学
- 脂质代谢 脂质代谢是什么
- 动脉样硬化研究 动脉样硬化研究
背景情况:
- 阿波脂蛋白E (apoE) 对于清除富含胆固醇的脂蛋白至关重要.
- 假设缺乏apoE会导致超脂血症和动脉样硬化.
- 创建了缺乏ApoE的小鼠来研究这个假设.
研究的目的:
- 为了测试apoE缺乏导致动脉样硬化的假设.
- 建立自发性动脉样硬化的小鼠模型.
- 评估apoE缺乏小鼠对动脉样硬化研究的有用性.
主要方法:
- 用基因向来制造缺少apoE的小鼠.
- 测量了血胆固醇的水平.
- 随着时间的推移,对大动脉动脉样硬化病变的发展进行了评估.
主要成果:
- 与正常小鼠相比,ApoE缺乏的小鼠的血胆固醇水平是正常小鼠的五倍.
- 富含泡细胞的动脉样硬化病变在3个月前在近道大动脉中形成.
- 在8个月后观察到严重的冠状动脉骨封闭.
结论:
- 在小鼠中,ApoE缺乏导致严重的高胆固醇血和自发性动脉样硬化.
- 缺乏ApoE的小鼠代表了研究动脉样硬化的可行和有价值的模型.
- 这种模型可以用来研究影响动脉生成的因素.
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