不对称隔膜缩和心肌纤维失调. 正常心脏的特征,发育中的心脏和有缺陷的心脏的特征
Circulation
|August 1, 1977
概括
非对称隔膜缩 (ASH) 和心肌纤维乱并不是异常性缩性下大动脉狭窄症 (IHSS) 的特征. 这些发现发生在正常发育的心脏和某些先天性疾病中,表明它们不是IHSS的最终标志物.
科学领域:
- 心血管病理学心血管病理学
- 发育生物学 发展生物学
- 心脏形态学 心脏形态学
背景情况:
- 不对称隔膜缩 (ASH) 和心肌纤维乱在异常性缩性下大动脉狭窄 (IHSS) 的诊断特异性仍然不清楚.
- 了解这些特征在各种心脏病的起源和患病率对于准确诊断至关重要.
研究的目的:
- 在多种心脏样本中调查ASH和心肌纤维混乱的发生和意义.
- 确定这些形态发现是否对IHSS具有病理性.
主要方法:
- 对来自正常个体的215颗心脏进行了组织学检查,包括发育阶段 (胚胎到成年人) 和患有先天性或获得性心脏病的人.
- 对正常心脏与病态心脏中隔膜形态和心肌纤维布局的比较分析.
主要成果:
- 在所有胚胎和一些心脏异常中观察到不成比例的隔膜加厚 (ASH),特别是那些患有右心室缩 (RVH) 的胚胎.
- 心肌纤维失调存在于所有心脏的特定结点,在半月膜缩和Fallote四重症等疾病中发现了广泛的失调.
- 在非IHSS条件下发现了ASH和显著的纤维混乱.
结论:
- 非对称隔膜缩 (ASH) 是正常心脏发育的特征,可以存在于与右心室缩 (RVH) 的心脏形中.
- 显著的心肌纤维失调可能发生在与异常的收缩相关的先天性心脏病变中.
- 无论是ASH还是心肌纤维乱,单独或组合,都不是异常性缩性下大风管狭窄症 (IHSS) 的病理特征.
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