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Updated: Jun 29, 2026

An Automated Differential Nuclear Staining Assay for Accurate Determination of Mitocan Cytotoxicity
07:58

An Automated Differential Nuclear Staining Assay for Accurate Determination of Mitocan Cytotoxicity

Published on: May 12, 2020

免疫学上确定的和有能力的细胞受到actinomycin D的不同影响.

E WEILER

    Science (New York, N.Y.)
    |May 15, 1964
    PubMed
    概括

    阿克提诺米辛D有差异地影响小鼠抗体形成细胞. 预处理抑制了对先前抗原的反应,但不抑制后续抗原的反应,揭示了不同的细胞记忆机制.

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    Apparent trans-chromosomal antibody class switch in mice bearing an Igh(a) mu-chain transgene on an Igh(b) genetic background.

    Immunobiology·1999

    科学领域:

    • 免疫学 免疫学 免疫学
    • 细胞生物学 细胞生物学

    背景情况:

    • 抗体生产对于适应性免疫至关重要.
    • 细胞记忆决定了对反原体重复暴露的反应.

    研究的目的:

    • 为了研究actinomycin D对抗体形成细胞容量的影响.
    • 为了区分对初级和二级免疫反应的影响.

    主要方法:

    • 在试验室中,小鼠腹液细胞被用actinomycin D治疗.
    • 细胞被转移并暴露于序列抗原.

    主要成果:

    • 阿克提诺米辛D抑制了对转移前抗原的抗体形成.
    • 细胞对转移后抗原的反应能力没有受到影响.

    结论:

    • 乙胺 D 选择性地损害了延迟的免疫反应.
    • 这表明最初和随后的抗原识别有不同的分子途径.
    关键词:
    在ACTINOMYCIN中使用.抗体的形成.抗原 - 抗体反应实验室研究实验室研究美国的米饭.药理学 在药理学方面.辐射免疫学 辐射免疫学毒理学报告 毒理学报告移植免疫学 移植免疫学

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